H-Y antigen gene loci
نویسندگان
چکیده
منابع مشابه
H-Y antigen and homosexuality in men.
In men, sexual orientation correlates with the number of older brothers, each additional older brother increasing the odds of homosexuality by approximately 33%. It is hypothesized that this fraternal birth order effect reflects the progressive immunization of some mothers to Y-linked minor histocompatibility antigens (H-Y antigen) by each succeeding male fetus, and the concomitantly increasing...
متن کاملMapping the H-Y gene.
This paper uses cytotoxic and proliferative T cell clones specific for H-Y and restricted by MHC molecules to type mice and humans inheriting incomplete portions of the Y chromosome. The data have allowed us to map the H-Y antigen gene Hya in mouse to a position closely linked with, but separable from, Tdy on the Sxr fragment and thus presumably to a position of the normal mouse Y chromosome ne...
متن کاملThe human UTY gene encodes a novel HLA-B8-restricted H-Y antigen.
The mammalian Y chromosome encodes male-specific minor histocompatibility (H-Y) Ags that are recognized by female T cells in an MHC-restricted manner. Two human H-Y epitopes presented by HLA-A2 and HLA-B7, respectively, have been identified previously and both are derived from the SMCY gene. We previously isolated CD8+ CTL clones that recognized a male-specific minor histocompatibility Ag prese...
متن کاملH-Y antigen and the growth of the dominant gonad.
The evolutionary conservation of H-Y antigen and its expression in the heterogametic sex regardless of whether this is male or female must mean that the antigen is associated with a common denominator underlying the development of mammalian testes and avian ovaries. It is suggested that one such common denominator is an enhanced growth rate of the dominant heterogametic gonad at a critical stag...
متن کاملH-Y antigen and the evolution of heterogamety.
In natural populations of platyfish, Xiphophorus maculatus, there are three sex chromosomes--W, X, and Y. Females may have one of three genotypes: WY, WX, or XX, and males may have either XY or YY. The W chromosome can be considered a modified X that blocks the male-determining function of the Y. The platyfish may represent an evolutionary stage at which female heterogamety arises through a sin...
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ژورنال
عنوان ژورنال: Science
سال: 1978
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.567373